99% RAD140 Testolone Sarms Raw powder CAS 1182367-47-00

Product Description

Name: RAD-140

CAS No.: 1182367-47-00

Other Names: RAD140 RAD 140, Testolone

Purity: 99%min

Brand Name: BIG BULL LAB

Grade: Pharm Medicine Grade

MFG: Fresh batch in 2023

Shelf Life: 2 years of proper storage

Appearance: White Powder

Test Reports: MS/COA/HPLC

MOQ: 10 grams raw powder.

Packing: discreet package.

Shipping: by express or post.

RAD140 (TESTOLONE) DESCRIPTION

RAD140 (Testolone) is a potent, orally bioavailable, investigational nonsteroidal selective androgen receptor modulator (SARM) devoloped by Radius Health, Inc. as a future substitute of exogenous Testosterone replacement therapy (TRT). Current RAD140 research focuses on its potential benefits in increasing muscle mass, fighting muscle wasting, skeleton wasting (osteoporosis), breast cancer and protecting brain cells. RAD140 Testolone has chemical formula C20H16ClN5O2 and molecular mass 393.83 g·mol−1.

RAD140 HAS EXCELLENT AFFINITY FOR THE ANDROGEN RECEPTOR

RAD140 demonstrated excellent affinity for the androgen receptor (Ki = 7 nM versus 29 nM for testosterone and 10 nM for dihydrotestosterone (DHT)) as well as good selectivity over other steroid hormone nuclear receptors, with the closest off target receptor being the progesterone receptor (IC50 = 750 nM vs 0.2 nM for progesterone). In vitro functional androgen agonist activity was confirmed in the C2C12 osteoblast differentiation assay, where an EC50 of 0.1 nM was shown (DHT = 0.05 nM).

RAD140 EFFECTIVELY STIMULATES THE GROWTH OF MUSCLE MASS

A clinical study published in 2011 examined the anabolic androgenic effect of RAD140 in young primates, male cynomolgous monkeys. The results on animal body weight of 28-day dosing with RAD140 at 0.01 mg/kg, 0.1 mg/kg, and 1 mg/kg are shown in the following figure:

In this study, a mean weight gain of greater than 10% in just 28 days of dosing was achieved at a dose of just 0.1 mg/kg. A similar result was achieved also in the 1.0 mg / kg dose group.