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CAS Number:29342-05-0
Name:Ciclopirox
Formula: C12H17NO2
Molecular Weight: 207.2689
Synonyms:2(1H)-Pyridone,6-cyclohexyl-1-hydroxy-4-methyl- (8CI);2(1H)-Pyridinone,6-cyclohexyl-1-hydroxy-4-methyl-;HOE 296b;Penlac;
EINECS:249-577-2
Density:1.193 g/cm3
Melting Point:144 °C
Boiling Point:350 °C at 760 mmHg
Flash Point:165.5 °C
Solubility: soluble in methanol, ethanol or chloroform
Appearance: white or light-yellow powder
| ITEMS | SPECIFICATION | RESULTS |
| Appearance | White or yellow-white,crystalline powder | Complies |
| Identification | Infrared absorption: conforms to standard | Complies |
| Related substance |
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| Heavy metals | Not more than 10ppm | Complies |
| Loss on drying | Not more than 1.5 per cent | 0.38% |
| Sulphate ash | Not more than 0.1 per cent | 0.05% |
| Assay | 98.0 per cent to 101.0 per cent,calculated on the dried substance | 100.9% |
| Conclusion: The product complies with USP35 standard | ||
1.Pyridine ketones broad-spectrum antifungal agents, have inhibiting effects on a variety of skin fungi . They can prevent the substances necessary for Candida albicans cells survival such as amino acids, potassium ions, phosphate,going through the cell membrane ,which can cause by certain important matrix or intracellular ions failure,and then inhibit or kill fungal cells. There are a wide range of anti-fungal effects, they can have a killing effect on the skin filamentous bacteria, yeast fungi , they have inhibition effects on a variety of Gram positive and negative bacteria, chlamydia, trichomoniasis, Proteus, E. coli, Pseudomonas and Staphylococcus bacteria. They are used to treat fungal skin disease, tinea versicolor, vulvovaginal Candida disease, skin and fingers (toe) candidiasis ,they have significant effects , and lower side effects.
2.Broad spectrum antimycotic agent with some antibacterial activity
3.Ciclopirox (Penlac) is a synthetic antifungal agent. Ciclopirox (Penlac) is used for topical dermatologic treatment of superficial mycoses. Ciclopirox (Penlac) is most useful against Tinea versicolor. [1] In a study conducted to further elucidate ciclopir
