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Product Name naphazoline nitrate
Molecular Formula C14H16N3O3
Molecular Weight 274.2946
CAS Registry Number 5144-52-5
EINECS 225-915-4
Melting point 167-170°C
Boiling point 527.8°C at 760 mmHg
Flash point 273°C
| Items | Standard | >Results | |||||
| Appearance | White or off-white powder | White powder | |||||
| Identification | IR | Exhibits maxima as that of reference standard | Conforms | ||||
| HPLC | The RT of the major peak in the chromatogram of the sample corresponds to that of the reference standard, as obtained in the assay. | Conforms | |||||
| Loss on Drying | ≤0.5% | 0.01% | |||||
| Residue on Ignition | ≤0.1% | 0.02% | |||||
| Heavy Metals | ≤10ppm | <10ppm | |||||
| Assay(dried basis), HPLC | 98.0 ~102.0% | 101.3% | |||||
| Related Compounds, HPLC | Max, individual impurity ≤ 0.1% Total impurities ≤ 1.0% | 0.05% 0.24% | |||||
| Residual Solvents, GC | n-hexane ≤100ppm Acetone ≤3000ppm Ethyl acetate ≤1000ppm Dichloromethane ≤600ppm Chloroform ≤60ppm | 1.2ppm 55.6ppm N/D 8.7ppm N/D | |||||
| Conclusion: This batch conforms as per above specifications. | |||||||
Naphazoline nitrate is an adrenergic vasoconstrictor agent used as a decongestant.
