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1.Name:Chlorphenamine Maleate
2.Cas No:113-92-8
3.MF:C16H19ClN2.C4H4O4
4.MW.:390.87
5.Appearance:white crystalline powder
6.Other Names: Chlorphenamine hydrogen maleate; 1-p-Chlorophenyl-1-(2-pyridyl)-3-dime
7.appearance:white crystalline powder
8.meilting point :131.5~135°C
9.Loss on drying: meet therequirment
10.residue on ignition: less than 0.1%
11.Assay: not less than 98.5%
12.usage: Anti-Ulcerative colitis
| Items | Specification |
| Appearance | White or almost white powder |
| Identification | Meets the requirements |
| Specific Rotation | -0.10 ~ +0.10° |
| Water | ≤0.5% |
| Heavy Metals | ≤0.002% |
| Redidue in Ignition | ≤0.2% |
| Related Substances | Meets the requirements |
| Benzene Sulfonic Acid | 27.3 ~ 28.7% |
| Ethanol | ≤300ppm |
| Toluene | ≤60ppm |
| Benzene | ≤2ppm |
| Acetic Acid | ≤600ppm |
| Methylamine | ≤20ppm |
| Ethyl Benzene Sulfonate | ≤5ppm |
| Particle Size | Meets the requirements |
| Assay | 98.0 ~102.0% |
| Standard | USP33 |
Chlorpheniramine Maleate is a small molecule H1-receptor antagonist. Increased ornithine decarboxylase activity induced in an ischemia-reperfusion state was attenuated by Chlorpheniramine Maleate, indicating that this increase is mediated through engagement of the H1-receptor by histamine.Histamine-mediated repair of intestinal mucosa following ischemiareperfusion was also demonstrated to operate through the H1-receptor with Chlorpheniramine Maleate. Induction of ornithine decarboxylase was blocked by Chlorpheniramine Maleate in Ehrlich carcinoma and MCF-7 cells. The positive inotropic effect of H1-receptor stimulation by histamine on protein tyrosine phosphorylation in guinea pig left atrium was antagonized by Chlorpheniramine Maleate.
