Producer in China and a Synthetic Estrogen Ester; β -Estradiol 17-Cypionate; CAS: 313-06-4

Product Description

Product name:β-Estradiol 17-cypionate

Synonyms:Depofemin;β-Estradiol 17-Cyclopentylpropionate;Estradiol Cypionate;

CAS : 313-06-4 Quality : 396.26600

MF : C26H36O3 logP : 6.13050

MW : 396.56200 PSA : 46.53000

Physical and chemical properties

Introduction of compounds

Estradiol cypionate (INN, USAN) (brand names Depo-Estradiol, Depofemin, Estradep, and many others), or estradiol cipionate, also known as estradiol 3-cyclopentylpropionate, is a synthetic estrogen ester, specifically the 3-cyclopentylpropanoyl ester, of the natural estrogen estradiol. It was first introduced in 1952 by Upjohn in the United States, and has been in widespread use since. Estradiol cypionate behaves as a sustained-release prodrug to estradiol, and therefore is considered to be natural estrogen.

Estradiol cypionate is absorbed more slowly than estradiol itself, and for that reason, can be administered less often. Compared to other commonly used estradiol esters, via the intramuscular route, estradiol cypionate was found to have the longest duration of action with a duration of ~11 days, while estradiol benzoate and estradiol valerate were found to last for 4-5 days and 7-8 days, respectively.

Estradiol cypionate, as a depot injection, has been found to have equivalent effectiveness and pharmacokinetics (e.g., duration) via subcutaneous and intramuscular routes. However, subcutaneous injection is generally regarded as easier and less painful relative to intramuscular injection, and for these reasons, may result in comparatively greater patient compliance.

use

Long-term estrogen.