Can HGH really bring people back to their childhood?

Can growth hormone really make people "rejuvenate their old age"? Professor of Endocrinology, Changhai Hospital Affiliated to Zhangjiaqing Second Military Medical University, delaying aging agents? In 1990, the New England Journal of Medicine published an article that caused a shock in the medical community. In this study, 12 men over 60 years of age were treated with recombinant human growth hormone (rhGH) and found that their body fat decreased, muscle weight increased, skin elasticity increased, and they looked healthier. Decreased blood lipids may also reduce the risk of cardiovascular disease, hair growth faster than before, and mood improvements. The authors do not propose recombinant human growth hormone as an anti-aging or anti-aging drug, but say that these changes are tantamount to bringing these elderly back to their "prime" years 10-20 years ago. This article has triggered some similar studies in the future, and positive results have been obtained, but all of them are small samples (at most dozens of cases), and the medication time is not long. However, this research has attracted the attention of the business community. Many "anti-aging health products" (nutritional supplements) consisting of vitamins, herbs and other ingredients have been launched. Advertisements claim that they can promote the secretion of growth hormone and thus delay aging. These health products have caused confusion in public perception. In 2003, the New England Journal of Medicine published two articles at the same time, one by the current editor-in-chief and the other by the editor-in-chief of the magazine in 1990. They all clearly believe that recombinant human growth hormone as a drug to delay aging is insufficient evidence. The 1990 article and similar studies since then have been small samples, have not been used for a long time, and have not emphasized enough on adverse reactions. High-dose and long-term use of recombinant human growth hormone can lead to adverse reactions such as hypertension, arthralgia, limb edema, carpal tunnel syndrome, diabetes mellitus and male breast development. Even when applied to childhood dwarfism, France has found a slight increase in total child mortality, so the Food and Drug Administration of the United States (FDA) has added safety warnings to the drug label. Subsequent studies also found that continued use of growth hormone-stimulating drugs, even pure recombinant human growth hormone, either orally or intramuscularly, resulted in resistance after several months (i.e., some of the previous good effects gradually disappeared). Because some growth hormone secretion drugs can also promote the secretion of "adrenocorticotropic hormone (ACTH)", increase the cortisol secreted by the adrenal gland, thereby blocking the role of growth hormone. Merck Pharmaceutical Company of the United States originally developed an oral growth-promoting hormone secretion (MK-677), which was also abandoned for the above reasons. Growth hormone, as its name implies, is a growth-promoting hormone. It is secreted by the human pituitary gland, on which each of us can grow from a newborn baby to an adult. Li Zhuohao (1913-1987), a well-known Chinese-American pituitary endocrine biochemist, has been engaged in the study of human growth hormone for a long time and is known as the "father of pituitary hormone". Professor Li Zhuohao spent 32 years in the discovery, extraction, purification, identification, determination of amino acid sequence and elucidation of chemical structure. Until 1970, he finally synthesized growth hormone artificially. This protein, composed of 256 amino acids, was the largest synthetic protein molecule at that time. After Professor Li Zhuohao discovered growth hormone, some people tried to use it to treat dwarfism caused by lack of growth hormone in children, but most of them were unsuccessful because of different growth hormones in various animals. Only one doctor who extracted monkey growth hormone from the pituitary gland of a certain kind of monkey achieved a clinical effect. In 1960, the United States established a special organization to collect the pituitary from autopsy nationwide and extract human growth hormone (hGH) for the treatment of pituitary dwarfism in children. Other developed countries have also learned this method, and more than 27,000 cases have been treated worldwide. In 1985, some of these children developed the deadly Creutzfeldt-Jakob disease, known as "mad cow disease" today. The study found that these patients had used human growth hormone extracted from cadavers 10 to 15 years ago, and the authorities immediately banned it. Professor Li Zhuohao has synthesized human growth hormone (hGH), which has prompted manufacturers to apply recombinant DNA biotechnology to mass production and has not been widely used in clinical practice until today. The physiological function of growth hormone (also known as somatotropin abroad) is secreted from pituitary gland, but it also has an "axis". Unlike gonads and thyroid glands, it does not have a target gland, but directly acts on organs and tissues of the whole body to promote growth and regenerate cells. Growth hormone has a characteristic that it enters the liver and produces insulin-like growth factor-1 (IGF-1), which can also play a role in promoting growth. The pituitary gland is controlled by the hypothalamus, which secretes growth hormone releasing hormone (GHRH) and somatostatin. The former promotes and the latter inhibits the secretion of growth hormone. These two factors are balanced by various external factors (such as sleep, exercise, stress, etc.), which lead to the secretion or Non-secretion of growth hormone (inhibition). The secretion of growth hormone is impulsive, i.e. in bursts. The peak appeared in the first deep sleep about an hour after sleep, and the EEG showed slow waves. The third and fourth deep sleep also had lower peaks. It secretes very little during the day, but only for a period of time after 3 to 5 hours. As a result, children who are excited during the day and fall asleep in bed at night grow taller, while those who cannot sleep normally grow taller. Human life-long growth hormone