How to judge whether it is short? Can growth hormone help grow taller?

At present, the FDA-approved genetically modified human growth hormone (rhGH) indications are: growth hormone deficiency (GHD), growth disorders associated with renal failure before renal transplantation in children; osteophytes have been completely closed, and the growth potential of children is very limited. Growth hormone has not played any role.

Doctor Profile: Director of Children's Health Department of Yixian People's Hospital, concurrently a member of the Children's Health Management Committee of Shandong Provincial Hospital Association, the first member of the Behavioral Health Professional Committee of the Children's Health Area of ​​Shandong Health Management Association, and the second member of Rizhao Medical Association: Scientific Professional Committee, Sunshine Member of the Municipal Women and Children Nutrition Professional Committee, an adjunct professor at Shandong Medical College. Engaged in pediatric clinical 12 years, child care 10 years. Indications for a variety of pediatric common diseases, children's psychological behavior problems, short stature, sexual precocity and other growth and development issues. Received the third prize of municipal science and technology progress award, two first prizes of county-level scientific and technological progress award, three second prizes; more than ten national and provincial papers, two utility model patents, and participated in the new Editor-in-Chief of the Child Care Guide.

Short stature means that the child's height is less than the third percentile of the average height of children of the same race, age, and gender. But in fact, children's developmental age and height may not be exactly the same, and indeed some children with short heights are late. For example, some children may be 9 years old, but the bone age is only 6 or 7 years old. If his bone age is less than two years behind the actual age, other growth conditions are normal. As long as the current growth rate can reach 5-7 cm a year, it means that the growth rate is not slow. This kind of child tends to think that it is late.

The human developmental age is highly heritable. For example, the mother developed late, only 15 to 6 years old to come to menstruation, indicating that the family's genetic predisposition is late. I have collected nearly 100 such cases. These children grew up late and grew slowly. When others have not grown up, he began to grow. It may be 20 or 30 years old to catch up with normal people.

Parents must regularly monitor their child's height and compare it with their peers to compare with their previous year's height to understand their growth rate. If the growth rate is normal and the bone age is within the normal range, these children can continue to observe and are not in a hurry to treat. I am afraid that parents always think that the child is late, and found that they missed the best treatment time. Therefore, if you are not sure, it is best to let the doctor judge whether the child is late or really short. The doctor will comprehensively evaluate the height, bone age and growth and development.

Special emphasis: I hope that when parents bring their children to the clinic, they must bring the information together and must tell the doctor about the growth of the child. At present, 70% of parents can't tell the height of their children last year at the time of the visit, how much has been in the last half year.

So, can growth hormone help to grow taller?

Human Growth Hormone (hGH) is a peptide hormone secreted by the anterior pituitary gland of human body and consists of 191 amino acids. Growth hormone stimulates the growth of insulin-like growth factor (IGF-1) by promoting the development of insulin-like growth factor (IGF-1), promotes bone growth, promotes anabolism and protein synthesis, promotes lipolysis, and inhibits glucose utilization. During puberty, growth hormone, under the synergistic effect of sex hormones, further causes rapid growth in height.

The US Food and Drug Administration (FDA) and the China Food and Drug Administration (CFDA) have approved only the growth hormone for the only effective drug for treating children's dwarfs. At present, the FDA approved genetically modified human growth hormone (rhGH) indications are: growth hormone deficiency (GHD), growth disorders associated with renal failure before renal transplantation in children; AIDS-related metabolic diseases and wasting; Turner syndrome with growth Obstacle; Prader-Willi syndrome; small for gestational age; idiopathic short stature; short bowel syndrome; SHOX gene defect without GHD in children.

Before 2005, the domestic growth hormone dosage forms were freeze-dried powder injections. When used, they were dissolved in water for injection and injected subcutaneously 30 minutes to 60 minutes before going to sleep every day. Because many children are afraid of injections, the child's compliance is relatively poor. At present, China has a domestically produced growth hormone water injection. The appearance of this dosage form eliminates the inconvenience and worry caused by the dissolution of the drug to the parents. With the use of the injection pen, the injection dose of the child is more accurate and the curative effect is more secure. At the same time, China has also developed a long-acting growth hormone once a week, which will be administered once a week for seven times a week, which can significantly reduce the pain of injections in children. Parents and children will no longer worry about getting injections every day, which will greatly expand the range of applications of growth hormone.

For children with short stature, the sooner they are treated, the better. The epiphysis has been completely closed, and the growth potential of the child is very limited at this time, and growth hormone has no effect.